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In enzymology, an acyl-CoA oxidase (EC 1.3.3.6) is an enzyme that catalyzes the chemical reaction

acyl-CoA + O₂ trans-2,3-dehydroacyl-CoA + H₂O₂

Thus, the two substrates of this enzyme are acyl-CoA and O₂, whereas its two products are trans-2,3-dehydroacyl-CoA and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is acyl-CoA:oxygen 2-oxidoreductase. Other names in common use include fatty acyl-CoA oxidase, acyl coenzyme A oxidase, and fatty acyl-coenzyme A oxidase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, polyunsaturated fatty acid biosynthesis, and ppar signaling pathway. It employs one cofactor, FAD.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1IS2, 1W07, 2DDH, 2FON, 2IX5, and 2IX6.

References

• IUBMB entry for 1.3.3.6
• BRENDA references for 1.3.3.6 (Recommended.)
• PubMed references for 1.3.3.6
• PubMed Central references for 1.3.3.6
• Google Scholar references for 1.3.3.6
• T, Kikuchi T, Ando M, Okuda S (Tokyo). "Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase". J. Biochem.: 1481–6. PMID 7462191. 
• Osumi T, Hashimoto T, Ui N (Tokyo). "Purification and properties of acyl-CoA oxidase from rat liver". J. Biochem.: 1735–46. PMID 7400120. 

External links

The CAS registry number for this enzyme class is 61116-22-1.

• IUBMB entry for 1.3.3.6

• KEGG entry for 1.3.3.6

• BRENDA entry for 1.3.3.6

• NiceZyme view of 1.3.3.6

• EC2PDB: PDB structures for 1.3.3.6

• PRIAM entry for 1.3.3.6

• PUMA2 entry for 1.3.3.6

• IntEnz: Integrated Enzyme entry for 1.3.3.6

• MetaCyc entry for 1.3.3.6

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0003997: acyl-CoA oxidase

• AMIGO entry for GO code 0003997: acyl-CoA oxidase

This EC 1.3 enzyme-related article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

• This page was last modified on 25 July 2008, at 00:48.

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