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Adapalene
Systematic (IUPAC) name
6-[3-(1-adamantyl)-4-methoxy-phenyl] naphthalene-2-carboxylic acid
Identifiers
CAS number	106685-40-9
ATC code	D10AD03
PubChem	60164
DrugBank	APRD00780
Chemical data
Formula	C28H28O3
Mol. mass	412.52 g/mol
Pharmacokinetic data
Bioavailability	Very low
Metabolism	?
Half life	?
Excretion	Biliary
Therapeutic considerations
Pregnancy cat.	C
Legal status	POM(UK) ℞-only(US)
Routes	Topical

Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.¹ It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India.

Contents 1 Indications 2 History 3 Dosage 4 Available Forms 5 Pharmacology 5.1 Drug Interactions 5.2 Pharmacodynamics 5.3 Pharmacokinetics 6 External links 7 References

Indications

Adapalene is indicated for the topical treatment of acne vulgaris.

History

Adapalene was approved in 1996 by the U.S. Food and Drug Administration for use in the treatment of acne.

Dosage

Adapalene is applied once daily, after washing and before retiring. In some circumstances, when a patient complains of skin irritation, this may be decreased to once every other day until the irritation ceases.

Available Forms

In the United States, adapalene is available under the brand name Differin in three different preparations: 0.1% cream, 0.1% gel, and 0.3% gel.²In Europe, only the 0.1% Cream and 0.1% Gel are available.

Pharmacology

Drug Interactions

Adapalene has been shown to enhance the efficacy of topical clindamycin. Application of adapalene gel to the skin 2-5 minutes before application of clindamycin enhances the overall efficacy of the treatment as compared to clindamycin alone.^{citation needed}

Unlike Retin-A, adapalene has also been shown to retain its efficacy when applied at the same time as benzoyl peroxide due to its more stable chemical structure.

Pharmacodynamics

Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. It has both exfoliating and anti-inflammatory effects. The exact mode of action of adapalene is unknown.

Pharmacokinetics

Adapalene is applied topically to the skin, and its absorption into the blood through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.

External links

• Differin product insert

References

1. ^ Rolewski S (2003). "Clinical review: topical retinoids". Dermatol Nurs 15 (5): 447–50, 459–65. PMID 14619325, http://www.medscape.com/viewarticle/464026. 
2. ^ About Differin

v • d • e Acne-treating agents (D10) Antibacterial agents Azelaic acid • Benzoyl peroxide • blue light therapy • Tea tree oil Kerolytic agents Glycolic acid • Salicylic acid Anti-inflammatory agents Aspirin • Ibuprofen• red light therapy Antibiotics Clindamycin • Erythromycin • Sulfacetamide • Tetracyclines • Trimethoprim Hormonal Antiandrogens • Contraceptives Retinoids Adapalene • Isotretinoin • Tazarotene • Tretinoin

Wikipedia content modification information:

• This page was last modified on 18 November 2008, at 03:05.

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