Amiloride

This MedLibrary.org supplementary page on Amiloride is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Amiloride
Systematic (IUPAC) name
3,5-diamino-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide
Identifiers
CAS number 2016-88-8
ATC code C03DB01
PubChem 16231
DrugBank APRD00790
Chemical data
Formula C6H8ClN7O 
Mol. mass 229.627 g/mol
Pharmacokinetic data
Bioavailability Readily absorbed
Metabolism none
Half life 6 to 9 hours
Excretion unchanged in urine
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes oral

Amiloride is a potassium-sparing diuretic, first approved for use in 1967 (then known as MK 870), used in the management of hypertension and congestive heart failure.

Contents

Structure

Amiloride is a guanidinium group containing pyrazine derivative.

Mode of action

Amiloride works by directly blocking the epithelial sodium channel (ENaC) thereby inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys (this mechanism is the same for triamterene). This promotes the loss of sodium and water from the body, but without depleting potassium. The drug is often used in conjunction with thiazide (e.g. co-amilozide) or loop diuretics (e.g. co-amilofruse). Due to its potassium-sparing capacities, hyperkalemia (high blood potassium levels) are occasionally observed in patients taking amiloride. The risk is high in concurrent use of ACE inhibitors or spironolactone. Patients are also advised not to use potassium-containing salt replacements.1 Amiloride also carries the risk of developing an acidosis.

A fraction of the effects of amiloride is inhibition of cyclic GMP-gated cation channels in the inner medullary collecting duct.2

See also

References

  1. ^ LoSalt Advisory Statement (PDF)
  2. ^ Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3.  page 875
v • d • e
Membrane transport modulators
Channel blocker
Dihydropyridines ("-dipine")
1-4 Benzothiazepines ("-tiazem")
Other/ungrouped
Amrinone  • Anandamide  • Anipamil  • Azimilide  • Bencyclane  • Bepridil  • Berbamine  • Bevantolol  • Canadine  • Carboxyamido-Triazole  • Cinnarizine  • Conotoxins  • Darodipine  • Dauricine  • Devapamil  • Dimeditiapramine  • Dotarizine  • Emopamil  • Enpiperate  • Eperisone  • Falipamil  • Fantofarone  • Fasudil  • Fenamic acid  • Fendiline  • Flunarizine  • Fosfedil  • Gabapentin  • Lamotrigine  • Lidoflazine  • Magnesium sulfate  • Manoalide  • Mepirodipine  • Mibefradil  • Monatepil  • Naftopidil  • Niguldipine  • Niludipin  • Norverapamil  • Ochratoxin A  • Octylonium  • Osthol  • Oxodipine  • Perhexiline  • Pinaverium  • Piperidine  • Prenylamine  • Risedronic acid  • Ryodipine  • Sesamodil  • Stepholidine  • Terodiline  • Tetrahydropalmatine  • Tetrandrine  • Tolfenamic acid  • Tranilast
Amiloride  • Encainide  • Pilsicainide  • Saxitoxin • Tetrodotoxin  • Tocainide
Symporter inhibitor
v • d • e
Antihypertensives: diuretics (C03)
CA inhibitors (at PT)
Loop diuretic (Na-K-Cl at AL)
Thiazides (Na-Cl at DCT)
Other sulfonamides/
thiazide-like diuretics (primarily DCT)
Potassium-sparing (at CD)
Osmotic diuretics (PT, DL)
Mannitol # • Urea
Vasopressin antagonists (DCT and CD)
Other
# = WHO-EM
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 15 December 2008, at 12:52.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Amiloride".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.