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Cafestol
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| Systematic (IUPAC) name | |
| (3bS,5aS,7R,8R,10aS,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro- 7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol |
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| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C20H28O3 |
| Mol. mass | 316.439 g/mol |
| Physical data | |
| Melt. point | 158–162 °C (316–324 °F) |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Legal everywhere |
| Routes | Oral |
Cafestol is a diterpene molecule present in coffee.
A typical bean of Coffea arabica contains about 0.6% cafestol by weight. Cafestol is present in highest quantity in unfiltered coffee drinks such as French press coffee or Turkish coffee. In filtered coffee drinks such as drip brewed coffee, it is present in only negligible amounts.
Studies have shown that regular consumption of boiled coffee increases serum cholesterol by 8% in men and 10% in women. For those drinking filter coffee, the effect was only significant for women.citation needed
Cafestol has also shown anticarcinogenic properties in rats.citation needed
According to a 2007 study from Dr. David Moore's lab at Baylor College of Medicine[1], cafestol may act as an agonist ligand for the nuclear receptor Farnesoid X receptor and Pregnane X receptor, blocking cholesterol homeostasis.
See also
External links
- NIH review of toxicology of cafestol and kahweol
- The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors
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Wikipedia content modification information:
- This page was last modified on 17 November 2008, at 14:35.
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