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Charles Brenner is a Professor in the Departments of Genetics and Biochemistry at Dartmouth Medical School. He is also Associate Director for Basic Sciences at Norris Cotton Cancer Center. He is a graduate of Wesleyan University and a veteran of biotechnology companies, having worked at Chiron Corporation and DNAX Research Institute, prior to graduate school at Stanford University School of Medicine. Brenner did post-doctoral work at Brandeis University with Gregory A. Petsko and then took his first academic position at Thomas Jefferson University in 1996 before moving to Dartmouth in 2003.1
Brenner has made multiple contributions to molecular biology, beginning with purification and characterization of the Kex2 proprotein convertase at Stanford.2 He has been funded by agencies including the Leukemia & Lymphoma Society, the March of Dimes, the Burroughs Wellcome Fund, the Beckman Foundation, the National Institutes of Health, and the National Science Foundation. Active research projects include molecular dissection of the function of the FHIT tumor suppressor gene,3 quantitative analysis of RING finger domain ubiquitin ligases,4 and discovery of new steps in nicotinamide adenine dinucleotide metabolism. Notably, the Brenner laboratory discovered that yeast and human enzymes use nicotinamide riboside to make NAD+,5 for which Brenner was recognized with a William E.M. Lands lectureship at University of Michigan. Brenner is author of more than 70 publications and the senior editor of the 2004 book, Oncogenomics: Molecular Approaches to Cancer.
Monograph
- Charles Brenner and David Duggan (2004) Oncogenomics: Molecular Approaches to Cancer. John Wiley & Sons, Hoboken, NJ. ISBN 0471225924
References
- ^ http://www.dartmouth.edu/~brenner/cv.html
- ^ Brenner, C, Fuller, RS (1992). "Structural and Enzymatic Characterization of a Purified Prohormone-Processing Enzyme: Secreted, Soluble Kex2 Protease". Proc. Natl. Acad. Sci. 89: 922–926. PMID 1736307.
- ^ Trapasso, F et al (2003). "Designed FHIT Alleles Establish that Fhit-Induced Apoptosis in Cancer Cells is Limited by Substrate-Binding". Proc. Natl. Acad. Sci. 100: 1592–1597. PMID 12574506.
- ^ Loring, GL, Christensen, KC, Gerber, GA, Brenner, C (2008). "Yeast Chfr Homologs Retard Cell Cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-Dependent Ubiquitination". Cell Cycle 7: 95–105. PMID 18202552.
- ^ Bieganowski, P, Brenner, C (2004). "Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans". Cell 117: 495–502. PMID 15137942.
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