Diacylglycerol lipase

This MedLibrary.org supplementary page on Diacylglycerol lipase is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

diacylglycerol lipase, alpha
Identifiers
Symbol DAGLA
Alt. Symbols C11orf11
Entrez 747
HUGO 1165
RefSeq NM_006133
UniProt Q9Y4D2
Other data
Locus Chr. 11 q12.3
diacylglycerol lipase, beta
Identifiers
Symbol DAGLB
Entrez 221955
HUGO 28923
RefSeq NM_139179
UniProt Q8NCG7
Other data
Locus Chr. 7 p22.1

Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.1 It catalyzes the hydrolysis of diacylglycerol releasing a free fatty acid and monoacylglycerol.

Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.

Inhibitors

The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.

References

  1. ^ Bisogno, T. et al. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J. Cell. Biol. 2003 (163)3:463. Article

External links

v • d • e
Hydrolase: esterases (EC 3.1)
3.1.1: Carboxylic ester hydrolases
3.1.2: Thioesterase
3.1.3: Phosphatase
3.1.4: Phosphodiesterase
3.1.6: Sulfatase
other
v • d • e
Metabolism: lipid metabolism - eicosanoid metabolism enzymes
Precursor
Phospholipase A2
Phospholipase C · Diacylglycerol lipase
Prostanoids
Leukotrienes
see also eicosanoids

Wikipedia content modification information:

  • This page was last modified on 3 November 2008, at 00:00.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Diacylglycerol lipase".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.