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| Dimethylethanolamine | |
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| IUPAC name | 2-(dimethylamino)ethanol |
| Other names | dimethylamino ethanol Deanol |
| Abbreviations | DMAE |
| Molecular formula | C4H11NO |
| Molar mass | 89.14 |
| CAS number | 108-01-0 |
| Density | 0.89 g/mL |
| Melting point |
-70 |
| Boiling point |
133-134 |
| SMILES |
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| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Dimethylaminoethanol, also known as DMAE or dimethylethanolamine, is an organic compound. This compound also goes by the names of N,N-dimethyl-2-aminoethanol, beta-dimethylaminoethyl alcohol, beta-hydroxyethyldimethylamine and Deanol. It is a liquid with a color that ranges from clear to pale yellow.
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Industrial uses
Dimethylaminoethanol is used as a curing agent for polyurethanes and epoxy resins. It is also used in mass quantities for water treatment, and to some extent in the coatings industry. It is used in the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals, emulsifiers, and corrosion inhibitors. It is also an additive to paint removers, boiler water and amino resins.
Biochemical precursor
Dimethylaminoethanol is related to choline and is a biochemical precursor to the neurotransmitter acetylcholine, and found naturally in fish like sardines and anchovies. It is reported to have nootropic effects, although research on this chemical has found both positive and negative potential results.
It is believed that dimethylaminoethanol is methylated to produce choline in the brain1. It is known that dimethylaminoethanol is processed by the liver into choline; however, the choline molecule is charged and cannot pass the blood-brain barrier.
Research
Short term studies have shown an increase in vigilance and alertness, with a positive influence on mood.2 Long term studies are equivocal. Some showed dimethylaminoethanol to increase the lifespan of animals in which it was tested, while others indicate a possible reduction in the average life span of quail.3 With the uncertainty of whether this could be extrapolated to humans, dimethylaminoethanol supplementation is not generally recommended. It is possible that dose is a major determining factor in the overall effects of dimethylaminoethanol - a high dose could produce effects opposite to those sought and contribute to life-shortening.4
See also
References
- ^ N. R. Zahniser, D. Chou, I. Hanin. "Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation", Journal of Pharmacology and Experimental Therapeutics 200(3):545–559, 1977.
- ^ W. Dimpfel, W. Wedekind, I. Keplinger, "Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states", European Journal Medical Research 8(5):183-191, 2003.
- ^ A. Cherkin, M.J. Exkardt, "Effects of dimethylaminoethanol upon life-span and behavior of aged Japanese quail", Journal of Gerontology 32(1):38-45, 1977.
- ^ G. Morissette, L. Germain, F. Marceau, "The antiwrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology", British Journal of Dermatology 156(3) pp.433-439, 2007.
Studies
- Earliest research
- As a treatment for tardive dyskinesia
- Haug BA, Holzgraefe M. "Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)?" European Neurology 31(6):423–425, 1991. [2]
- As an unsuccessful treatment for Alzheimer's disease
- Fisman M, Mersky H, Helmes E. "Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease." American Journal of Psychiatry 138(7):970–972, 1981. [3]
- As a treatment for attention-deficit hyperactivity disorder
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- This page was last modified on 8 September 2008, at 09:07.
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