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Enoyl-acyl carrier protein reductase (or ENR) (EC 1.3.1.9), is a key enzyme of the type II fatty acid synthesis (FAS) system. (PMID 15139852) ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes. (PMID 15105103)
At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR.
See also
- Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)
- Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)
- Cis-2-enoyl-CoA reductase (NADPH)
External links
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Wikipedia content modification information:
- This page was last modified on 11 March 2008, at 14:18.
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