Erythropoietin receptor

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Erythropoietin receptor
Available structures: 1cn4, 1eba, 1ebp, 1eer, 1ern
Identifiers
Symbols EPOR; MGC138358
External IDs OMIM: 133171 MGI: 95408 HomoloGene: 95
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2057 13857
Ensembl ENSG00000187266 ENSMUSG00000006235
Uniprot P19235 Q3UTV9
Refseq NM_000121 (mRNA)
NP_000112 (protein)		 XM_978769 (mRNA)
XP_983863 (protein)
Location Chr 19: 11.35 - 11.36 Mb Chr 9: 21.71 - 21.71 Mb
Pubmed search [1] [2]

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.1

References

  1. ^ "Entrez Gene: EPOR erythropoietin receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2057. 

Further reading

  • Zhu Y, D'Andrea AD (1999). "The molecular physiology of erythropoietin and the erythropoietin receptor.". Curr. Opin. Hematol. 1 (2): 113–8. PMID 9371269. 
  • Lacombe C, Mayeux P (1998). "Biology of erythropoietin.". Haematologica 83 (8): 724–32. PMID 9793257. 
  • Bonifacino JS (2002). "Quality control of receptor-kinase signaling complexes.". Dev. Cell 2 (1): 1–2. PMID 11782306. 
  • Takeshita A, Shinjo K, Naito K, et al. (2003). "Erythropoietin receptor in myelodysplastic syndrome and leukemia.". Leuk. Lymphoma 43 (2): 261–4. PMID 11999556. 
  • Kralovics R, Skoda RC (2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders.". Blood Rev. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213. 
  • Madeddu P, Emanueli C (2007). "Switching on reparative angiogenesis: essential role of the vascular erythropoietin receptor.". Circ. Res. 100 (5): 599–601. doi:10.1161/01.RES.0000261610.11754.b1. PMID 17363704. 

External links

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Transmembrane receptors: immune receptors
Cytokine receptor
CSF1 · C-kit · IL-1 · IL-18
Other
IL-17 · TGF-beta (1, 2)
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Antigen receptor
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Receptors: growth factor receptors
Nerve growth factors
Somatomedin
CSF
Stem cell factor - Erythropoietin
TGF pathway
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Wikipedia content modification information:

  • This page was last modified on 8 July 2008, at 02:46.

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