Flurbiprofen

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Flurbiprofen
Systematic (IUPAC) name
2-(3-fluoro-4-phenyl-phenyl)propanoic acid
Identifiers
CAS number 5104-49-4
ATC code M01AE09 M02AA19, S01BC04
PubChem 3394
DrugBank APRD00753
Chemical data
Formula C15H13FO2 
Mol. mass 244.261 g/mol
Physical data
Melt. point 117 °C (243 °F)
Pharmacokinetic data
Bioavailability  ?
Protein binding > 99%
Metabolism Hepatic (CYP2C9)
Half life 4.7-5.7 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C (U.S.), B2 (Au)
Legal status

POM
Routes Oral

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis. It is known by the following tradenames: Ansaid, marketed by Pfizer, and Froben, by Abbott.

Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges.

The single enantiomer of racemate flurbiprofen, tarenflurbil (R-flurbiprofen), is currently in clinical trials for the treatment of metastatic prostate cancer and Alzheimer's disease.


Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
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Topically used products
Bendazac · Diclofenac · Etofenamate · Felbinac · Flurbiprofen · Ibuprofen · Indometacin · Ketoprofen · Naproxen · Piroxicam · Suprofen
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Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.
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Propionic acid class

Fenoprofen · Flurbiprofen · Ibuprofen · Ketoprofen · Naproxen · Oxaprozin
Oxicam class
Acetic acid class
Anthranilic acid
(fenamate) class
Atypical, adjunct
& miscellaneous

Wikipedia content modification information:

  • This page was last modified on 8 November 2008, at 18:33.

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