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Novartis International AG

Type	Public (SWX: NOVN) (NYSE ADRs: NVS)
Founded	1996 (from merger)
Headquarters	Basel, Switzerland
Key people	Daniel Vasella (CEO)
Industry	Pharmaceuticals
Products	Diovan, Exelon, Lamisil, Gleevec, Lotrel, Zometa, Neoral, Femara Zelnorm, Benefiber, Clomicalm, Voltaren, Tegretol, Reclast etc.
Revenue	▲US$ 38 billion (2007)1
Employees	98,200 (2008)1
Divisions	Consumer healthcare, pharmaceuticals production, vaccines and diagnostics, generic pharmaceuticals production, research and development
Subsidiaries	Ciba Vision, Sandoz
Website	www.novartis.com

Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland that manufactures drugs such as clozapine (Clozaril), diclofenac (Voltaren), carbamazepine (Tegretol), valsartan (Diovan), imatinib mesylate (Gleevec / Glivec), cyclosporin A (Neoral / Sandimmun), letrozole (Femara), methylphenidate hydrochloride (Ritalin), terbinafine (Lamisil), and others. Novartis owns Sandoz, a large manufacturer of generic drugs. The company formerly owned the Gerber Products Company, a major infant and baby products producer, but sold it to Nestlé on 1 September 2007.^{2 3}

Novartis is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA).⁴

Contents 1 Collaborative Research 2 History 2.1 Ciba-Geigy 2.2 Sandoz 2.3 After the merger 3 Products 3.1 Pharmaceuticals 3.2 Consumer Health (OTC) 4 Research and Development 5 Challenge to India's patent laws 6 Relationship with Huntingdon Life Sciences 7 References 8 External links

Collaborative Research

In addition to internal research and development activities Novartis is also involved in publicly funded collaborative research projects, with other industrial and academic partners. One example in the area of non-clinical safety assessment is the InnoMed PredTox.⁵⁶ The company is expanding its activities in joint research projects within the framework of the Innovative Medicines Initiative of EFPIA and the European Commission.⁷

History

Novartis was created in 1996 from the merger of Ciba-Geigy and Sandoz Laboratories, both Swiss companies with long histories. At the time it was said to be the largest corporate merger in history. Ciba-Geigy was formed in 1970 by the merger of J. R. Geigy (founded in Basel in 1758) and Ciba (founded in Basel in 1859). Considering the histories of the merger partners, the company's history spans 250 years.⁸

Ciba-Geigy

Johann Rudolf Geigy-Gemuseus (1733 – 1793) began trading in 1758 in "materials, chemicals, dyes and drugs of all kinds" in Basel, Switzerland. Johann Rudolf Geigy-Merian (1830 – 1917) and Johann Muller-Pack acquire a site in Basel in 1857, where they build a dyewood mill and a dye extraction plant. Two years later, they begin the production of synthetic fuchsine. In 1901 Geigy is transformed into a public limited company and in 1914, the name of the company is changed to J.R. Geigy Ltd.

In 1859 Alexander Clavel (1805 – 1873) takes up the production of fuchsine in his factory for silk dyeing works in Basel. In 1864, a new site for the production of synthetic dyes is constructed, and in 1873, Clavel sells his dye factory to the new company Bindschedler & Busch. In 1884 Bindschedler & Busch is transformed into a joint-stock company with the name "Gesellschaft für Chemische Industrie Basel" (Company for Chemical Industry Basel). The abbreviation CIBA becomes so widespread that it was adopted as the company's name in 1945.

In 1925 J.R. Geigy Ltd. starts producing textile auxiliaries, an activity which Ciba takes up in 1928.

In 1939, Geigy chemist Paul Hermann Müller discovered that DDT was effective against malaria-bearing insects. He received the Nobel Prize in Medicine for this work in 1948.

Ciba and Geigy merged in 1971 to form Ciba‑Geigy Ltd., and this company merged with Sandoz in 1996 to form Novartis.

Sandoz

Sandoz is perhaps best known for synthesizing LSD in 1938⁹. This was later marketed under the trade name Delysid as a psychiatric treatment from 1947 through the early 1960s. The Chemiefirma Kern & Sandoz ("Kern & Sandoz Chemistry Firm") was founded in 1886 by Dr. Alfred Kern (1850–1893) and Edouard Sandoz (1853–1928). The first dyes manufactured there were alizarine blue and auramine. After Kern's death, the partnership was changed to the corporation Chemische Fabrik vormals Sandoz in 1895. The company began producing the fever-reducing drug antipyrin in the same year.

Between the World Wars, Gynergen (1921) and Calcium-Sandoz (1929) were brought to market. Sandoz also produced chemicals for textiles, paper, and leather beginning in 1929. In 1939, they began producing agricultural chemicals.

From 1899, the sugar substitute saccharin was produced. Prior to the merger of Sandoz and Ciba-Geigy to form Novartis in 1996, Sandoz also engaged in drug development. Pharmaceutical research began in 1917 under Professor Arthur Stoll (1887–1971). In 2005, Sandoz expanded significantly though the acquisition of Hexal, one of Germany’s leading generics company, and Eon Labs, a fast-growing U.S. generic pharmaceutical company.

The psychedelic effects of lysergic acid diethylamide (LSD) were discovered at the Sandoz laboratories in 1943 by Albert Hofmann. Sandoz began clinical trials, and marketed the drug under the name Delysid as a psychiatric drug thought useful for treating a wide variety of mental ailments, from alcoholism to sexual deviancy. Sandoz suggested in its literature that psychiatrists take LSD themselves¹⁰, to gain a better subjective understanding of the schizophrenic experience, and many did exactly that. For several years, the psychedelic drugs were also called "psychotomimetic" because they were thought to mimic psychosis. Later research caused this term to be abandoned, as neuroscientists gained a better understanding of psychoses, including schizophrenia. Research on LSD peaked in the 1950s and early 1960s. Sandoz withdrew the drug from the market in the mid 1960s.

Sandoz opened its first foreign offices in 1964.

In 1967, Sandoz merged with Wander AG (known for Ovomaltine and Isostar). Sandoz acquired the companies Delmark, Wasabröd (Swedish manufacturer of crisp bread), and Gerber Products Company baby food makers.

On November 1, 1986, a fire broke out in a production plant storage room, which led to a large amount of pesticide being released into the upper Rhine. This exposure killed many fish.

In 1995, Sandoz spun off its speciality chemicals business to form Clariant. Subsequently, in 1997, Clariant merged with the speciality chemicals business that was spun off from Hoechst in Germany.

After the merger

After the merger, Novartis reorganized its activities, and spun out its chemicals activities as Ciba Specialty Chemicals.

In 1998 the company made headlines with its biotechnology licensing agreement with the UC Berkeley Department of Plant and Microbial Biology. Critics of the agreement expressed concern over prospects that the agreement would diminish academic objectivity, or lead to the commercialization of genetically modified plants. The agreement expired in 2003.

Novartis combined its agricultural division with that of AstraZeneca to create Syngenta in November 2000.

In 2003, Novartis created Sandoz, a subsidiary that bundles its generic drug production, reusing the brand of one of its predecessor companies.

On April 20, 2006 Novartis acquired the California-based Chiron Corporation. Chiron was formerly divided into three units: Chiron Vaccines and Chiron Blood Testing, which now combine to form Novartis Vaccines and Diagnostics, and Chiron BioPharmaceuticals, to be integrated into Novartis Pharmaceuticals.

The ongoing Basel Campus Project has the aim to transform the St. Johann site - Novartis headquarters in Basel - "from an industrial complex to a place of innovation, knowledge and encounter". ¹¹

On 2005, Novartis introduced Certican (Everolimus), an immunosuppressant.

On October 2006, Novartis introduced Telbivudine, a new antiviral drug for hepatitis B.

Products

Pharmaceuticals

• Diovan- $5.0 B sales¹² (2007)- Hypertension
• Gleevec- $3.1 B- for Chronic myeloid leukemia
• Zometa- $1.3 B (2007)- Cancer complications
• Sandostatin - $1.0 B (2007) - Acromegaly
• Sandimmun Neoral- $944 M (2007)- Transplantation
• Femara- $937 M (2007)- Breast cancer
• Lotrel- $748 M (2007)- Hypertension
• Voltaren- $747 M (2007)- Inflammation
• Trileptal- $692 M (2007)- Epilepsy
• Lescol- $665 M (2007)- cholestrol
• Exelon- $632 M (2007)- Alzheimer's disease
• Comtan- $420 M (2007)- Parkinson's disease
• Tegretol- $413 M (2007)- Epilepsy
• Lucentis- $393 M (2007)- Age-related macular degeneration
• Ritalin- $375 M (2007) - ADD
• Exjade- $357 M (2007) - Iron chelator
• Tobramycin- $273 M (2007)- Cystic fibrosis
• Termalgin - (Paracetamol and compounds.) - Treatment of fever and light pain.

Consumer Health (OTC)

Triaminic, Theraflu, Lamisil, Benefiber, Nicotinell, Bufferin, Buckley's cold and cough formula, Denavir/Vectavir, Desenex, Excedrin, Ex-Lax, Gas-X, Keri skin care, Maalox, Habitrol, No-doz, Tavist, Vagistat, Doan's pain relief, Lamisil foot care, Comtrex cold and cough

Research and Development

Major therapeutic areas:

• autoimmunity/transplantation/inflammatory disease
• cardiovascular disease
• diabetes
• gastrointestinal disease
• infectious diseases
• musculoskeletal disease
• neuroscience
• oncology
• ophthalmology
• respiratory disease

Challenge to India's patent laws

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In 2006, Novartis launched a court case against India seeking to prohibit the country from developing generic drugs based on patented medicines.¹³Novartis had challenged a law that allows India to refuse to recognize a patent for an existing medicine if there is a modified formula resulting in a re-patent of the drug.¹⁴ On August 5, 2007 an Indian court in Chennai ruled against Novartis saying that, "Novartis’ legal challenge - mounted to limit competition to its own patented medicines - was a threat to people suffering from cancer, HIV and AIDS, diabetes and other diseases who are too poor to pay for them."¹⁵ The high court also claimed to have no jurisdiction on whether Indian Patent law complied with WTO patent guidelines.

In the months leading up to the hearing, over half a million people wrote to the CEO of Novartis expressing their opposition to the suit. Novartis has decided not to appeal the ruling.¹⁶

Relationship with Huntingdon Life Sciences

The company and its shareholders have been targeted by animal rights activists because it is a customer of Huntingdon Life Sciences, a controversial animal testing company that has been the subject of an international campaign by Stop Huntingdon Animal Cruelty and the Animal Liberation Front. After footage shot covertly by People for the Ethical Treatment of Animals (PETA) aired on British television showing HLS staff abusing animals, Novartis offices were vandalized, and its executives' homes picketed.^{citation needed}

References

External links

• Novartis
• Sandoz
• Genomics Institute of the Novartis Research Foundation
• Chiron Corporation
• Novartis acquisition of Chiron approved by Chiron shareholders
• Basel Campus Project
• Novartis Employees Association
• Novartis Anti-HLS Campaign

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• This page was last modified on 22 November 2008, at 11:20.

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