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Glucose phosphate isomerase
Enzyme Glucose-6-phosphate isomerase PDB Code PDB 1GZV Organism Pig Tissue Muscle Complexed molecules 5-phosphoarabinoate
Symbol(s):	GPI
Genetic data
Locus:	Chr. 19 q13.1
Database Links
EC number:	5.3.1.9
Entrez:	2821
OMIM:	172400
RefSeq:	NM_000175
UniProt:	P06744

Glucose-6-phosphate isomerase, or phosphoglucose isomerase, is an enzyme (EC 5.3.1.9) that catalyzes the conversion of glucose-6-phosphate into fructose-6-phosphate in the second step of glycolysis. It should not be confused with "glucose isomerase", which is actually a common name for D-xylose isomerase (EC 5.3.1.5) in the high-fructose corn syrup industry.

The human variant of this enzyme is encoded by the GPI gene.

In glycolysis

α-D-Glucose 6-phosphate	Phosphoglucose isomerase		β-D-Fructose 6-phosphate
	Phosphoglucose isomerase

Compound C00668 at KEGG Pathway Database. Enzyme 5.3.1.9 at KEGG Pathway Database. Compound C05345 at KEGG Pathway Database. Reaction R00771 at KEGG Pathway Database.

As a glucose isomerase

D-Glucose	Phosphoglucose isomerase		D-Fructose
			[[image:]]
	Phosphoglucose isomerase

Other functions

There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by white blood cells, and acts to regulate the growth of several different cell types.

v • d • e  Glycolysis Metabolic Pathway

Glucose Hexokinase Glucose-6-phosphate Glucose-6-phosphate isomerase Fructose 6-phosphate 6-phosphofructokinase Fructose 1,6-bisphosphate Fructose bisphosphate aldolase ATP ADP ATP ADP Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Triosephosphate isomerase Glyceraldehyde 3-phosphate Glyceraldehyde-3-phosphate dehydrogenase 1,3-Bisphosphoglycerate Phosphoglycerate kinase NAD+ + Pi NADH + H+ ADP ATP + 2 2 3-Phosphoglycerate Phosphoglycerate mutase 2-Phosphoglycerate Phosphopyruvate hydratase(Enolase) Phosphoenolpyruvate Pyruvate kinase Pyruvate Pyruvate dehydrogenase Acetyl-CoA H2O ADP ATP CoA + NAD+ NADH + H+ + CO2 2 2 2 2 2

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• This page was last modified on 17 November 2008, at 17:53.

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