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Isofurans are nonclassic eicosanoids formed nonenzymatically by free radical mediated peroxidation of arachidonic acid. The isofurans are similar to the isoprostanes and are formed under similar conditions, but contain a substituted tetrahydrofuran ring. The concentration of oxygen affects this process; at elevated oxygen concentrations, the formation of isofurans is favored whereas the formation of isoprostanes is disfavored.1
References
- ^ Roberts, LJ 2nd and Fessel, JP (2004 Mar). "The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation.". Chem Phys Lipids 128 ((1-2)): 173–86.. doi:, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15037162. Retrieved on 5 January 2007. PMID: 15037162
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