LFA-1

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Lymphocyte function-associated antigen 1, also known as LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule, it is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate.

LFA-1 is part of the family of leukocyte integrins which are recognised by their common β-chains (CD18). LFA-1 also has a distinct α-chain (CD11a).

See also

Further reading

  • Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY

External links

  • MeSH LFA-1
  • Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA (1981). "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4535–9. PMID 7027264. 
v • d • e
Transmembrane receptors: immune receptors
Cytokine receptor
CSF1 · C-kit · IL-1 · IL-18
Other
IL-17 · TGF-beta (1, 2)
Other endogenous
Other
Exogenous
TLR 1 · TLR 2 · TLR 3 · TLR 4 · TLR 5 · TLR 6 · TLR 7 · TLR 8 · TLR 9 · TLR 10
Antigen receptor
Other
v • d • e
Membrane proteins: cell adhesion molecules
IgSF
Cadherins
Selectins
Integrins
LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa (Note: integrins not always classified as CAMs)
Other

Wikipedia content modification information:

  • This page was last modified on 15 November 2008, at 08:28.

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