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Neurofurans are 22-carbon compounds formed nonenzymatically by free radical mediated peroxidation of docosahexaenoic acid (DHA), an ω-3 essential fatty acid. The neurofurans are similar to the isofurans and are formed under similar conditions of oxidative stress, containing a substituted tetrahydrofuran ring. Measurement of the neurofurans may ultimately prove useful in diagnosis, timing and selection of dose in the treatment and chemoprevention of neurodegenerative disease. 1
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References
- ^ Song WL, Lawson JA, Reilly D, Rokach J, Chang CT, Giasson B, and FitzGerald GA. (2007). "Neurofurans: Novel indices of oxidant stress derived from docosahexaenoic acid". J Biol Chem 283: 6. doi:. PMID 17921521.
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