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tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
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| Identifiers | |
| Symbol | TAC1 |
| Alt. Symbols | TAC2, NKNA |
| Entrez | 6863 |
| HUGO | 11517 |
| OMIM | 162320 |
| RefSeq | NM_013998 |
| UniProt | P20366 |
| Other data | |
| Locus | Chr. 7 q21-q22 |
| Neurokinin A | |
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| Identifiers | |
| CAS number | 86933-74-6 |
| PubChem | |
| MeSH | |
| Properties | |
| Molecular formula | C50H80N14O14S |
| Molar mass | 1133.32 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Neurokinin A (formerly known as substance K) is a member of the tachykinin family of neuropeptide neurotransmitters. It is produced from the same preprotachykinin gene as the neuropeptide substance P. It has various roles in the body of humans and other animals. One specific example is mediating contraction of the rat colon. Neuropeptide K (which has also been called neurokinin K1)and neuropeptide gamma are N-terminally longer versions of neurokinin A, produced from the same splice forms of the same gene, which appear to be final peptide products in some tissues.2
References
- ^ Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior." Physiol Behav. 1993 Aug;54(2):249-58. PMID 7690487
- ^ Carter MS, Krause JE. "Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma." J Neurosci. 1990 Jul;10(7):2203-14. PMID 1695945
- Maggi C, Patacchini R, Rovero P, Giachetti A (1993). "Tachykinin receptors and tachykinin receptor antagonists". J Auton Pharmacol 13 (1): 23–93. PMID 8382703.
- Regoli D, Boudon A, Fauchére J (1994). "Receptors and antagonists for substance P and related peptides". Pharmacol Rev 46 (4): 551–99. PMID 7534932.
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