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A salvage pathway is a pathway in which nucleotides (purine and pyrimidine) are synthesized from intermediates in the degradative pathway for nucleotides.
Salvage pathways are used to recover bases and nucleosides that are formed during degradation of RNA and DNA. This is important in some organs because some tissues cannot undergo de novo synthesis.
The salvaged bases and nucleosides can then be converted back into nucleotides.
Contents |
Substrates
The salvage pathway requires distinct substrates:
Pyrimidines
Thymidine requires a substrate whose enzyme is called thymidine kinase
Purines
| Nucleoside | Enzyme | Nucleotide |
| hypoxanthine | hypoxanthine/guanine phosphoribosyl transferase (HGPRT) | IMP |
| guanine | hypoxanthine/guanine phosphoribosyl transferase (HGPRT) | GMP |
| adenine | adenine phosphoribosyltransferase (APRT) | AMP |
Lesch-Nyhan syndrome is associated with a deficiency of HGPRT.
External links
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Wikipedia content modification information:
- This page was last modified on 22 November 2008, at 13:23.
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