Rizatriptan

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Rizatriptan
Systematic (IUPAC) name
N,N-dimethyl-2- [5-(1,2,4-triazol-1-ylmethyl)- 1H-indol-3-yl]ethanamine
Identifiers
CAS number 145202-66-0
ATC code N02CC04
PubChem 5078
DrugBank APRD00008
Chemical data
Formula C15H19N5 
Mol. mass 269.345 g/mol
Pharmacokinetic data
Bioavailability 45%
Protein binding 14%
Metabolism by monoamine oxidase
Half life 2–3 hours
Excretion 82% urine; 12% faeces
Therapeutic considerations
Pregnancy cat.

C
Legal status
Routes Oral

Rizatriptan (Maxalt) is a 5-HT1 agonist triptan drug developed by Merck & Co. for the treatment of migraine headaches. It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).

Maxalt obtained approval by the United States Food and Drug Administration (FDA) on June 29, 1998. It is a second-generation triptan.

Rizatriptan is available only by prescription in the United States , Canada and New Zealand. Similarly, it is classed as a POM (Prescription Only Medicine) in the United Kingdom, Italy (as Rizaliv) and Israel (as Rizalt).

This medication is used to treat acute migraine attacks. It does not prevent future migraine attacks.

Indicated for:

Contraindications:

Side effects:

External links

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Serotonin agonists
5-HT1
Almotriptan • Eletriptan • Frovatriptan • Naratriptan • Rizatriptan • Sumatriptan • Zolmitriptan
5-HT2
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5-HT7
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Antimigraine preparations (N02C)
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Tryptamines

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Merck & Co., Inc.
Corporate Directors:
Products:
Publications:
Annual Revenue: $22.9 billion USD (▲2% FY 2004) · Employees: 63,000 · Stock Symbol: NYSE: MRK · Website: www.merck.com
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