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| (−)-Stepholidine | |
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-Stepholidine.svg) |
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| IUPAC name | 3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-bisoquinoline-2,10-diol |
| Other names | l-Stepholidine |
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| Properties | |
| Molecular formula | C19H21NO4 |
| Molar mass | 327.374 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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(−)-Stepholidine is a naturally-occuring chemical compound found in the herb Stephania intermedia. Stepholidine is a dual D2 receptor antagonist and D1 receptor agonist, and has shown antipsychotic activity in animal studies.1234
See also
References
- ^ Natesan S, Reckless GE, Barlow KB, et al (August 2008). "The antipsychotic potential of l-stepholidine-a naturally occurring dopamine receptor D(1) agonist and D (2) antagonist". Psychopharmacology (Berl.) 199 (2): 275–89. doi:. PMID 18521575.
- ^ Mo J, Guo Y, Yang YS, Shen JS, Jin GZ, Zhen X (2007). "Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications". Curr. Med. Chem. 14 (28): 2996–3002. PMID 18220736, http://www.bentham-direct.org/pages/content.php?CMC/2007/00000014/00000028/0007C.SGM.
- ^ Jin GZ, Zhu ZT, Fu Y (January 2002). "(-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions". Trends Pharmacol. Sci. 23 (1): 4–7. PMID 11804640, http://linkinghub.elsevier.com/retrieve/pii/S0165614700019295.
- ^ Fu W, Shen J, Luo X, et al (September 2007). "Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations". Biophys. J. 93 (5): 1431–41. doi:. PMID 17468175.
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- This page was last modified on 11 November 2008, at 03:51.
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