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| Theodor Boveri | |
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| Born | October 12, 1862 |
|---|---|
| Died | October 15, 1915 |
| Nationality | German |
| Fields | genetics |
| Known for | embryonic development Boveri-Sutton chromosome theory centrosome |
Theodor Heinrich Boveri (October 12, 1862–October 15, 1915) was a German biologist whose work with sea urchins showed that it was necessary to have all chromosomes present in order for proper embryonic development to take place. This discovery was an important part of the Boveri-Sutton chromosome theory. His other significant discovery was the centrosome (1888), which he described as the especial organ of cell division. Boveri also had discovered a phenomenon of chromatin diminution do embryonic development of nematode Parascaris.
He also reasoned that a cancerous tumor begins with a single cell in which the make up of its chromosomes becomes scrambled, causing the cells to divide uncontrollably.
It was only much later in the twentieth century that leading researchers came to believe that Boveri may have been correct.
References
- Baltzer, Fritz (1967), Theodor Boveri: The Life of a Great Biologist 1862-1915, http://www.devbio.com/article.php?ch=7&id=75, retrieved on 22 July 2007. Extract published in Gilbert, SF (2006), DevBio: a companion to Developmental Biology, 8th ed, Sinauer Associates
- Boveri, Theodor (2008), "Concerning The Origin of Malignant Tumours", Journal of Cell Science 121 (Supplement 1): 1–84, doi:, PMID 18089652, http://jcs.biologists.org/cgi/content/full/121/Supplement_1/1
- Maderspacher, Florian (2008), "Theodor Boveri and the natural experiment", Current Biology 18 (7): R279–R286, doi:
- Satzinger, Helga (March 2008). "Theodor and Marcella Boveri: chromosomes and cytoplasm in heredity and development". Nat. Rev. Genet. 9 (3): 231–8. doi:. PMID 18268510.
- Laubichler, Manfred D; Davidson Eric H (February 2008). "Boveri's long experiment: sea urchin merogones and the establishment of the role of nuclear chromosomes in development". Dev. Biol. 314 (1): 1–11. doi:. PMID 18163986.
- Bignold, Leon P; Coghlan Brian L D, Jersmann Hubertus P A (July 2006). "Hansemann, Boveri, chromosomes and the gametogenesis-related theories of tumours". Cell Biol. Int. 30 (7): 640–4. doi:. PMID 16753311.
- Hardy, Paul A; Zacharias Helmut (December 2005). "Reappraisal of the Hansemann-Boveri hypothesis on the origin of tumors". Cell Biol. Int. 29 (12): 983–92. doi:. PMID 16314117.
- Wunderlich, Volker (September 2002). "JMM---past and present. Chromosomes and cancer: Theodor Boveri's predictions 100 years later". J. Mol. Med. 80 (9): 545–8. doi:. PMID 12226736.
- Manchester, K L (July 1997). "Overlooked Nobel laureates". Adler Museum bulletin 23 (2): 20–1. PMID 11619485.
- Manchester, K (. 1997). "The quest by three giants of science for an understanding of cancer". Endeavour 21 (2): 72–6. doi:. PMID 9237430.
- Moritz, K B; Sauer H W (February 1996). "Boveri's contributions to developmental biology--a challenge for today". Int. J. Dev. Biol. 40 (1): 27–47. PMID 8735909.
- BALTZER, F (May. 1964). "Theodor Boveri". Science 144: 809–15. doi:. PMID 14149391.
- STERN, C (September 1950). "Boveri and the early days of genetics". Nature 166 (4219): 446. doi:. PMID 14775717.
Further reading
- Jane, Oppenheimer (1970-80). "Boveri, Theodor". Dictionary of Scientific Biography 2. New York: Charles Scribner's Sons. 361-365. ISBN 0684101149.
External links
- Wolbert, Peter, Theodor Boveri (1862-1915), Biocenter of the University of Wuerzburg, http://www.biozentrum2.uni-wuerzburg.de/en/more_infos/theodor_boveri_1862-1915/, retrieved on 22 July 2007
- Fritz Baltzer. (1967). excerpt from Theodor Boveri: The life of a great biologist, 1862-1915. University of California Press, Berkeley; pp. 85-97.
Wikipedia content modification information:
- This page was last modified on 3 November 2008, at 21:41.
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