Thiothixene

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Thiothixene
Systematic (IUPAC) name
(Z)-N,N-dimethyl-9-
[3-(4-methylpiperazin-1-yl)propylidene]-
thioxanthene-2-sulfonamide
Identifiers
CAS number 5591-45-7
ATC code N05AF04
PubChem 5454
DrugBank none
Chemical data
Formula C23H29N3O2S2 
Mol. mass 443.627
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 10-20 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

?
Routes oral

Thiothixene (sold as Navane) is a thioxanthene drug used as a typical antipsychotic medication. It is a thioxanthene derivative and is the cis isomer of N,Ndimethyl- 9-[3-(4-methyl-1-piperazinyl)-propylidene] thioxanthene-2-sulfonamide.


Navane is a first generation of antipsychotics, known as typical antipsychotics. Drugs in the second generation, known as atypical antipsychotics, have more recently been developed. Both classes of medication tend to block receptors in the brain's dopamine pathways, but antipsychotic drugs encompass a wide range of receptor specificity.

v • d • e
Dopamine antagonists
D1
D2
D3
D4
Other/unselective
Acepromazine • Alizapride • Amisulpride • Amoxapine • Azaperone • Benperidol • Blonanserin • Bromopride • Butaclamol • Chlorpromazine • Chlorprothixene • Clopenthixol • Domperidone • Droperidol • Eticlopride • Flupentixol • Flupenthixol decanoate • Fluphenazine • Fluspirilene • Haloperidol • Loxapine • Mesoridazine • Methotrimeprazine • Metoclopramide • Mosapramine • Nemonapride • Olanzapine • Penfluridol • Perazine • Perphenazine • Pimozide • Prochlorperazine • Promazine • Promethazine  • Quetiapine • Raclopride • Spiperone • Spiroxatrine • Stepholidine • Sultopride • Tetrahydropalmatine • Thiethylperazine • Thioridazine • Thiothixene • Tiapride • Trifluoperazine • Trifluperidol • Triflupromazine
v • d • e
Psycholeptics: antipsychotics - primarily dopamine antagonists (N05A)
Typical
Other
Atypical
Other D2 selective
D4 selective


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Wikipedia content modification information:

  • This page was last modified on 13 October 2008, at 02:52.

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