Wee (cell cycle)

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Identifiers
Symbol WEE1
Entrez 7465
HUGO 12761
OMIM 193525
RefSeq NM_003390
UniProt P30291
Other data
Locus Chr. 11 p15.3-15.1
WEE1 homolog 2 (S. pombe)
Identifiers
Symbol WEE2
Entrez 494551
HUGO 19684
Other data
Locus Chr. 7 q32-q32

Wee is a protein that operates at the G2 to M-phase checkpoint. Wee becomes active if errors occur in the DNA synthesis phase. It blocks entry into mitosis until the problem is resolved. Like Rb, wee becomes inactive when hyperphosphorylated.

Its name comes from the Scottish/Irish slang word wee, meaning small. This is because when mutated, the cells with this mutation exhibit a smaller than usual phenotype. The protein's discoverer, Paul Nurse, was working at the University of Edinburgh in Scotland at the time of discovery.

See also

External links

 This biochemistry article is a stub. You can help Wikipedia by expanding it.
v • d • e
Cell cycle proteins
Cyclin
D - E - A - B
Cyclin-dependent kinase
2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - CDK-activating kinase
Cyclin-dependent kinase inhibitor protein
Other

Wikipedia content modification information:

  • This page was last modified on 30 November 2008, at 22:57.

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